Here, we found rs73239138 might through impacting the regulatory role of miR-1269a in the expression of NME1, SHMT1, SLC29A1, TP53, and/or UCK1, contribute to the occurrence of adverse events in the advanced colon cancer patients reveived capecitabine-based chemotherapy. The gene discussed is TP53; the disease is malignant colon neoplasm.