Based on the hypothesis that YKL-40 levels in blood and tumor correlate, and that low YKL-40 enhances the effect of bevacizumab (VEGF neutralization), we tested the hypothesis that patients in AVAglio with low YKL-40 plasma concentrations will derive a greater benefit from bevacizumab than patients with higher YKL-40 plasma concentrations, due to the proposed interaction between VEGF, YKL-40, and tumor angiogenesis [11–18]. This evidence concerns the gene CHI3L1 and neoplasm.