However the roles of VEGF-A, CHD4 and TCF20 genes in CK20-related micrometastasis are unknown, the expression of them in LNs from Tumor-Node-Metastasis (TNM) stage III and IV CRC patients would be studied in order to know whether this micrometastasis pathway is preserved in metastatic LNs. This evidence concerns the gene VEGFA and colorectal carcinoma.