On the other hand, 3 patients (3/47 = 6%) developed recurrence even though they were CK20-negative in their pN0 LNs (data not shown) and this observation can show that CK20-related micrometastasis is only one of the major pathways which leads to recurrence and there may still have other pathway(s) promoting metastasis in pN0 CRC. Here, KRT20 is linked to colorectal carcinoma.