However the roles of VEGF-A, CHD4 and TCF20 genes in CK20-related micrometastasis are unknown, the expression of them in LNs from Tumor-Node-Metastasis (TNM) stage III and IV CRC patients would be studied in order to know whether this micrometastasis pathway is preserved in metastatic LNs. The gene discussed is CHD4; the disease is neoplasm.