Although IL-10 was documented to exert anti-tumor and antimetastatic activity by inhibiting angiogenesis by numerous lines of evidence which was further supported by the observed delay in progression or complete regression of tumor in murine models with the administration of recombinant human IL-10 [12, 13], the production of IL-10 by keratinocytes or tumor infiltrating cells has also been found to exhibit cancer-promoting ability by inducing cell proliferation and down-modulating the anti-tumor immune response in skin cancer [14]. The gene discussed is IL10; the disease is cancer.