IL10 and skin neoplasm: Although it is biologically plausible that IL-10 −1082G>A and −592C>A polymorphisms which are both able to affect IL-10 expression [34], could have impact on the susceptibility to skin cancer, the current evidence with the largest sample size to date provided a null outcome regarding the associations, for which the potential explanation is that a single polymorphism may have limited impact on the complicated pathogenesis of skin cancer than what we have anticipated.