In support of this, the study by Schoof et al. [25] observed no significant association for skin cancer risk when considering a single polymorphism of IL-10, however, they found that the haplotype ITAGC from distal as well as proximal polymorphic site −7400In/Del, −6752A/T, −3538A/T, −1087G/A (−1082G>A), −597A/C (−592C>A) of the IL-10 was significantly associated with a reduced risk of developing melanoma. This evidence concerns the gene IL10 and skin neoplasm.