The TGFβ isoforms represent prototypic members of the TGFβ superfamily and signal via a TGFβ receptor I (TGFβRI) and TGFβ receptor II (TGFβRII) heterodimeric complex; in addition to their function in normal growth and development, they also play key roles in several disease states including cancer [2–4]. The gene discussed is TGFB1; the disease is cancer.