In the DECIPHER database, all deletions referred to PMS ranging in size from 100 kb to over 9 Mb contain SHANK3, and 75% PMS cases carried the simple terminal deletions while approximately 25% cases were comprised of translocations in the 22q13 region, ring chromosome 22 and mosaics [23, 24]. The gene discussed is SHANK3; the disease is premenstrual tension.