SCN1A and epilepsy: A study by Stosser et al. (2017) found a 3.5% overall frequency of mosaicism in 893 epilepsy probands across 9 different genes including CDKL5, GABRA1, GABRG2, GRIN2B, KCNQ2, MECP2, PCDH19, SCN1A, and SCN2A. Mosaicism is thought to be an underreported cause of genetic disorders, due to detection challenges, although there are numerous studies aimed at improving this using NGS technology (Stosser et al., 2017).