CD4 and colitis: In addition, employing different mouse models of colitis including IL-10 knockout mice as well as adoptive T cell transfer models of colitis, it was shown that the genetic deletion of TRPA1 in CD4+ T cells caused intestinal inflammation via induction of the transcription factor Tbet which subsequently increased production of the pro-inflammatory cytokines IFN-γ and IL-2 (11) and resulted in a higher capacity to differentiate into TH1 effector cells.