Furthermore, we elected to study these effects in dermal fibroblast (DF) from three TRAPS patients, who harbored three different TNFRSF1A mutations, since many of the clinical manifestations of TRAPS are localized to fibroblast-rich tissues, and we wanted to show that this is not a mutation-specific phenomenon. The gene discussed is TNFRSF1A; the disease is TNF receptor 1-associated periodic fever syndrome.