KNG1 and colitis: In contrast to the protective phenotypes of Kng1−/− and B1RB2R−/− mice, the weight loss (Figure 6A), DAI scores (Figure 6B), colon shortening (Figure 6C), and histological changes (Figure 6D) in FXII−/− mice were comparable to those of WT mice, indicating that FXII is not involved in the pathogenesis of DSS-induced colitis.