Kng1−/− mice (Figures 13A–C), B1RB2R−/− mice (Figures 13D–F), or Klkb1−/− mice (Figures 14A–C) had significant protection against TNBS-induced colitis, as evidenced by the amelioration of body weight loss, colon length shortening, and histological changes. The gene discussed is KNG1; the disease is colitis.