NPPA and cancer: In keeping with the synergism of two different photosensitizers in combination to enhance PDT efficacy against cancer (Schneider-Yin et al., 2009; Villanueva et al., 2010; Gyenge et al., 2013; Acedo et al., 2014), we previously showed that L. amazonensis doubly sensitized with URO+PC in vitro was fully susceptible to in vivo photo-inactivation in BALB/c X C57BL/6 mice, producing no lesion and no detectable parasites 8 weeks after inoculation with 106 cells per site into their ear dermis (Dutta et al., 2012).