A potential explanation of this differential effect is as follows: (i) in the case of obese without diabetes, exercise intervention has decreased the stress load on the SAT and the overall body and thus the HSR levels are attenuated, whereas (ii) in the case of obese with diabetes, the HSR as reflected by HSP60 is enhanced to cope with the persistent cellular dysregulated status despite the apparent decreased inflammation. The gene discussed is HSPD1; the disease is diabetes mellitus.