In a subsequent study, they were also able to prove that Bcl2 phosphoyrlation and Bcl-2/Beclin 1 complex disruption played a key role in eliciting autophagy and diminishing mitochondrial damage in RIC rats after cerebral ischemia; this required the involvement of the AKT/GSK3β-dependent pathway acitvation (76). The gene discussed is BCL2; the disease is brain ischemia.