The role of IL-6 seems to be dose-dependent: several studies have confirmed the pro-inflammatory effects of IL-6 in atherosclerosis models (Hartman and Frishman, 2014), but a complete loss of IL-6 increases plaque formation and serum cholesterol levels in ApoE−/− mice (Schieffer et al., 2004). This evidence concerns the gene IL6 and atherosclerosis.