Animals studies showed that ZAG overexpression in ob/ob and high-fat diet (HFD)-induced obese mice led to significant reductions in body weight and fat mass, as well as a decrease in insulin resistance (Gong et al., 2009; Russell and Tisdale, 2010), whereas ZAG-deficient mice gained more body weight and showed a remarked decrease in lipolysis on both standard and lipid-rich dietary regimens (Rolli et al., 2007). This evidence concerns the gene AZGP1 and Insulin resistance.