miR-542-3p could modulate expression level of p53 (Wang et al., 2014), cell apoptosis and was connected with cancer (Wang et al., 2016c), ischemic stroke (He et al., 2016), liver failure (Ding et al., 2015), neointimal formation (Qian et al., 2015), diabetic cardiomyopathy and osteogenesis (Chavali et al., 2014; Kureel et al., 2014). Here, TP53 is linked to ischemic stroke.