ERBB2 and dilated cardiomyopathy: The importance of ErbB2 in the heart has been particularly emphasized by seminal studies that demonstrated that ErbB2 cardiac KO mice were affected by dilated cardiomyopathy, with increased susceptibility to anthracycline-induced damage to cardiomyocytes (Crone et al., 2002; Ozcelik et al., 2002).