Since its introduction in 1998, trastuzumab has dramatically improved the clinical history of breast cancer patients, but unfortunately it has been shown to cause cardiac dysfunction (Bloom et al., 2016; Moslehi, 2016; Zamorano et al., 2016; Armenian et al., 2017), since ErbB2 has been proven to be an important modulator of myocardial function (Force et al., 2007; Eschenhagen et al., 2011). The gene discussed is ERBB2; the disease is breast carcinoma.