Moreover, the Asp358Ala (rs2228145) in IL6R was not associated with several traditional risk factors such as blood pressure, adiposity, hyperglycaemia, cholesterol, and smoking but with the concentration IL-6, C-reactive protein, fibrinogen, and coronary heart disease implying a causal role for this inflammatory pathway (IL6R Genetics Consortium Emerging Risk Factors Collaboration et al., 2012). This evidence concerns the gene IL6R and Hyperglycemia.