SH2B3 and coronary artery disorder: With the aim to investigate the genetic susceptibility to CAD, in a large study (63,746 CAD cases and 130,681 controls) performed by combining genome-wide data from the CARDIoGRAM and C4D consortia, Deloukas and colleagues found evidence that only the SNP rs3184504 at the SH2B3 locus displayed statistically significant association with CAD (CARDIoGRAMplusC4D Consortium et al., 2013).