Regarding genes involved in inflammatory pathway, C-X-C motif ligand 12 (CXCL12), SH2B adaptor protein 3 (SH2B3), AB0, Human Leukocyte Antigen (HLA), interleukin 6 receptor (IL-6R), IL-5, Platelet endothelial cell adhesion molecule 1 (PECAM1), Protein C Receptor (PROCR) and antisense non-coding RNA in the INK4 locus (ANRIL) have been identified in different GWAS and sometimes confirmed in case-controls studies as significantly associated to coronary artery disease (CAD) (Table 1). The gene discussed is IL6R; the disease is coronary artery disorder.