Overstimulation of P2X7 receptor with high levels of exogenous ATP in order to produce tumor cell death is a longstanding observation and it was demonstrated in many types of cancer, such as colon cancer (Bian et al., 2013; Mello et al., 2017a), prostate cancer (Shabbir et al., 2008), cervical cancer (Wang et al., 2004; Mello et al., 2014), endometrial cancer (Li et al., 2006), melanoma (White et al., 2009; Feng et al., 2011; Bian et al., 2013), squamous cell carcinomas (Deli and Csernoch, 2008), and glioma (Tamajusuku et al., 2010; Gehring et al., 2012, 2015), among others. This evidence concerns the gene P2RX7 and melanoma.