Evidence supporting this assumption comes from the fact that, in tumors overexpressing P2X7 receptor, such as neuroblastoma, the anti-tumoral effect of P2X7 antagonists is more pronounced in immune-competent than in immune-compromised (nude/nude) mice, indicating an additional contribution of the immune response against tumor in the former case (Amoroso et al., 2015; Di Virgilio and Adinolfi, 2017). This evidence concerns the gene P2RX7 and neoplasm.