In addition, P2X7 receptor antagonists significantly ameliorated 6-OHDA-induced decrease in mitochondrial respiration, as well as increase in oxidative stress and mitochondrial-linked apoptosis, adding preservation of mitochondrial function and integrity to the protective mechanisms of P2X7 receptor antagonists in PD (Kumar et al., 2017). Here, P2RX7 is linked to Parkinson disease.