More recently, in vitro autoradiography quantification of brain slices incubated with a potent iodinated radiotracer for P2X7 receptor, [123I]TZ6019, demonstrated higher binding in brains from P301C tau transgenic mice, a tauopathy mouse model of AD, compared to control (Jin et al., 2017). The gene discussed is P2RX7; the disease is Alzheimer disease.