P2RX7 and toxoplasmosis: P2X7 KO mice showed increased susceptibility to toxoplasmosis characterized by an impaired production of pro-inflammatory cytokines (IL-1β, IL-12, TNF-α, and IFN-γ) and increased tissue damage and parasitic load (Miller et al., 2011, 2015; Corrêa et al., 2017; Huang et al., 2017).