Supporting evidence for the involvement of P2X7 receptor in HD onset and development comes from the fact that BBG treatment prevented body weight loss and deterioration of motor coordination of R6/1 mouse model of HD as compared to vehicle-treated HD mice.This protective effect might be correlated with lower caspase-3 activation in neurons (Díaz-Hernández et al., 2009). Here, P2RX7 is linked to Huntington disease.