Considering P2X7 receptor role in promoting tumor angiogenesis via increased HIF1α activity and VEGF secretion (Adinolfi et al., 2012; Amoroso et al., 2012, 2015), it is tempting to say that the use of antagonists of P2X7 in association with anti-angiogenic drugs would surge synergistic effects in controlling tumorigenesis. Here, P2RX7 is linked to neoplasm.