In fact, extensive body of work has demonstrated the involvement of P2X7 receptor activation not only in microglia but also in neurons, oligodendrocytes, and astrocytes, in the development of multiple CNS disorders including Traumatic Brain Injury, Parkinson's disease, Alzheimer's disease, ischemia, epilepsy, Huntington's disease, and Multiple Sclerosis. Here, P2RX7 is linked to early-onset autosomal dominant Alzheimer disease.