In addition, P2X7 receptor is important for NLRP3 inflammasome activation and IL-1β secretion, which contributes to an efficient immune response against Chlamydiae infections (Abdul-Sater et al., 2010; He et al., 2010; Shimada et al., 2011; Nagarajan et al., 2012). The gene discussed is P2RX7; the disease is chlamydia infectious disease.