In their studies, retinoic acid-induced P2X7 receptor expression in CD4+ effector T cells in the intestine, by activation of the intragenic enhancer region of the P2X7 receptor mouse gene, inhibited excessive expansion of Th1 and Th17 cells in the intestine during colitis (Hashimoto-Hill et al., 2017). The gene discussed is P2RX7; the disease is colitis.