Rodent animal models of inflammatory bowel disease have shown that activation of P2X7 receptor induces death of enteric neurons and intestinal inflammation by activation of mast cells in the gut, leading to intestinal motility disorders (Gulbransen et al., 2012; Kurashima et al., 2012; Antonioli et al., 2014; Matsukawa et al., 2016). The gene discussed is P2RX7; the disease is inflammatory bowel disease.