P2RX7 and kidney disorder: Uncontrolled activation of P2X receptors, mainly P2X7 receptor, has been shown to play a critical role in the inflammatory reactions observed in renal diseases, contributing to renal glomerular, tubular, and vascular damage (Gonçalves et al., 2006; Deplano et al., 2013; Solini et al., 2013; Franco et al., 2015).