P2RX7 and inflammatory bowel disease: In this context, pharmacological inhibition of P2X7 receptor by BBG (Marques et al., 2014), A438079 (Wan et al., 2016), and A740003 (Marques et al., 2014; Figliuolo et al., 2017b) in animal models of inflammatory bowel disease showed beneficial effects attenuating the inflammatory response in the colon.