SQSTM1 and amyotrophic lateral sclerosis: SQSTM1, which has been identified in FTD in 2012 (Rubino et al., 2012), suggesting a role in the pathogenesis of neurodegenerative disease (Boutoleau-Bretonniere et al., 2015), is initially considered as a monogenic cause of Paget disease of bone (PDB) in 2002 (Laurin et al., 2002) and amyotrophic lateral sclerosis in 2011 (Fecto et al., 2011).