The BTB hinders hydrophilic molecules diffusing by paracellular transport into tumor tissues by endothelial TJ composed of integral membrane proteins (claudins, occludin, and junctional adhesion molecules) and intracellular proteins (ZO-1 and cingulin) (Miyoshi and Takai, 2005; Stamatovic et al., 2016). This evidence concerns the gene TJP1 and neoplasm.