In particular, the schizophrenia-associated proteins including dopamine transporter 1 (SLC6A3), receptor tyrosine-protein kinase erbB-4 (ERBB4), glutamate ionotropic receptor NMDA type subunit 1 (GRIN1), membrane associated guanylate kinase WW and PDZ domain containing 2 (MAGI2) and regulator of G-protein signaling 12 (RGS12) were also regulated by DISC1 (Mateos et al., 2006; Silberberg et al., 2006; Xu et al., 2011; Koide et al., 2012; Guipponi et al., 2014; Jaros et al., 2015; Zhang et al., 2015; Li et al., 2017). This evidence concerns the gene GRIN1 and schizophrenia.