Only four drugs are approved and currently used in symptomatic treatment for AD: acetylcholinesterase inhibitors, including donepezil (1997), rivastigmine (2000), and galantamine (2001), to ameliorate the clinical manifestations of AD by enhancing cholinergic neurotransmission in relevant parts of the brain (Birks et al., 2000; Olin and Schneider, 2002; Cacabelos, 2007); and memantine (2003), a N-methyl-D-aspartate receptor antagonist for improving AD behavioral symptoms (van Marum, 2009). This evidence concerns the gene ACHE and Alzheimer disease.