Even though tau in Sarkosyl-insoluble aggregates prepared from AD patient brains displayed a smeared banding pattern on the immunoblots after Laemmli's SDS-PAGE, their separation on Phos-tag suggests that several phosphorylated tau bands show similar mobility to hyperphosphorylated tau species in brains of perinatal mice or hypothermia mice. The gene discussed is MAPT; the disease is Alzheimer disease.