MAPT and early-onset autosomal dominant Alzheimer disease: Additionally, it is well known that hyperphosphorylated tau is a major component of neurofibrillary tangles (NFTs) in Alzheimer's disease (AD) (Ballatore et al., 2007; Spillantini and Goedert, 2013; Wang et al., 2013; Arendt et al., 2016).