Moreover, the enforced expression of UBE2I in two PCa cell lines markedly reduced the protein expression levels of CCND1 and MDM2 but increased the protein expression levels of RNASEL and CDKN1A (all P < 0.05, Fig. 7d), which were also opposite to the miR-188-5p enforced cells as mentioned above. The gene discussed is RNASEL; the disease is posterior cortical atrophy.