MDM2 and posterior cortical atrophy: As shown in Fig. 7a and b, the enforced expression of miR-193a-5p in two PCa cell lines, LNCaP and PC3, significantly reduced the protein expression levels of TP73, CCND1 and MDM2 but increased the protein expression levels of RNASEL and CDKN1A (all P < 0.05).