FN1 and coronary artery disorder: Mouse models of several CAD risk candidate genes (e.g. SCH1, RELA and FN1) in modules 82_4, 130_2 and 134_1 display phenotypes related macrophage accumulation and foam cell formation in atherosclerotic lesions78–80, thereby highlighting the roles of different immune system elements and signaling pathways these modules regulate in CAD.