TGFB1 and cutaneous melanoma: Analysis of transcriptomic data from a skin cutaneous melanoma (SKCM) data set (n = 472), using skin biopsy of healthy women (n = 122) as a reference, showed that upregulation in TGFβ signaling strongly correlated with increased messenger RNA expression levels of TGFB1 and FOXP3 (Fig. 1a, b).