As TNBC is representative of a tumor type that exhibits a TGFβ/FOXP3 signature of Treg-mediated immune tolerance (Fig. 1c), we used human immune reconstituted NSG mice bearing the bioluminescent human MDA-MB-231-luc (D3H2LN) TNBC cell line that expresses elevated PD-L1 (Fig. 5a, inset) and TGFβ (531 pg per 106 cells per 24 h) and exhibits enhanced lung metastases. The gene discussed is FOXP3; the disease is neoplasm.