With significantly higher frequencies of CD8+ TNFα+ and CD8+ CD107a+ T cells following the AM regimen compared with the A_M regimen, schedules with four-week intervals (AM or AAM) would fit well with the standard 6, 10, 14-week Expanded Programme on Immunization (EPI) schedule that is used for infant vaccinations in most countries where malaria is highly endemic. This evidence concerns the gene TNF and malaria.