TSC22D3 and breast cancer: PLX4032 limited the proliferation of cell lines carrying BRAFV600E29 (Fig. 2c) and significantly induced the upregulation of L-GILZ in 8505C and BC-PAP cells, and moderately upregulated L-GILZ in FTC-133 and TPC-1 cells (Fig. 2d), suggesting a correlation between MAPK inhibition-mediated antiproliferative activity and the upregulation of L-GILZ.