AURKA and brain neoplasm: To address this question we have investigated the mutational landscape of a cohort of tumors caused by mutations in l(3)malignant brain tumor (l(3)mbt), brain tumor (brat), aurora-A (aurA), and l(2)giant larvae (lgl), which are some of the most aggressive and best characterized larval brain tumors that can be induced in Drosophila (Wright et al. 1976; Gateff 1978; Humbert et al. 2003; Lee et al. 2006; Wang et al. 2006; Bowman et al. 2008).