VDR and intervertebral disk degenerative disorder: Furthermore, considering the VDR polymorphisms studied, TaqI polymorphism displayed a significant difference in the recessive model in the DD group, and the combination of wild-type alleles of TaqI, ApaI and FokI polymorphisms—TGT haplotype—was significantly frequent in controls, suggesting a lower risk of disc degeneration in carriers of these haplotypes.