The picture remains essentially the same with reduced cardiovascular and all cause mortality but neutral effects on stroke incidence (semaglutide in SUSTAIN-6 being the only GLP-1R agonist with significant effect on stroke incidence) by GLP-1R agonists [12, 13] and neutral results by DPP-4i [12, 14, 15]. The gene discussed is GLP1R; the disease is stroke disorder.