In the past few years, several large cardiovascular outcome trials employing GLP-1R agonists and DPP-4i in human subjects with T2D at increased cardiovascular risk have been concluded (reviewed by Nauck et al. [5], Avgerinos and Tziomalos [6] and Hemmingsen et al. [7]). Here, GLP1R is linked to type 2 diabetes mellitus.