MAPK8 and spinal cord injury: In spinal cord injury (SCI) rats, it was found that the effects of acupuncture stimulation of Shuigou (GV26) and Yanglingquan (GB34) in reducing mechanical and thermal hyperalgesia were mediated in part by down-regulating GFAP expression and inhibiting JNK activation in astrocytes at L4-L5 level of the spinal cord [41].