Interestingly, all tissues of T2D patients showed altered expression of genes involved in the inflammation response—such as SOCS1 in WB; CCL20 and SLAMF1 in SAT; ACP5, FOS, and JUN in VAT; and PLA2G2A in LT, showing the relevance of the systemic chronic inflammation in obesity and T2D [45]. Here, ACP5 is linked to obesity due to melanocortin 4 receptor deficiency.