IRS1 and obesity due to melanocortin 4 receptor deficiency: Several of the observed DMCs were located in genes related to T2D or obesity, such as ALOX12, PAMR1, and GNAS in WB; IRS1, LEP, and ADIPOQ in SAT; LCAT, FOXA2, KCNQ1, and GCKR in VAT; and PKD4, HNF4A, XBP1, and PON1 in LT.