TNF and obesity disorder: The classic paradigm proposes obesity as imbalance of positive energy intake, which results in expansion of adipose tissue, and subsequent proinflammatory process due to release of cytokines, C reactive protein (CRP), interferon gamma (IFNγ), Tumor Necrosis Factor alpha (TNFα), among many other molecules; additionally, increase of free fatty acids induces lipotoxicity [7–9].