As diathesis-stress research highlighted, the interaction of FKBP5 variability with childhood, but not adult trauma [15], has been found to confer risk for several psychopathological phenotypes [16], including depression [17, 18], psychosis [19, 20], anxiety [21], suicidal attempts [22, 23], aggression [24] and post-traumatic stress disorder [15, 25]. Here, FKBP5 is linked to major depressive disorder.