Given that the Erk pathway participates in isoprenaline (ISO)-induced cardiac hypertrophy in neonatal cardiomyocytes [1], it can be presumed that in terminally differentiated cardiomyocytes, sAC-dependent activation of B-Raf/Erk signaling may contribute to hypertrophic growth. This evidence concerns the gene MAPK1 and cardiac hypertrophy.