Given the essential role of the renal vasculature in maintaining adequate renal function and hemodynamics, coupled with the well-described role of the MR in protecting vessel function in chronic disease models [12, 24, 25], we aimed to delineate in detail the effects of MR deletion in the EC upon renal vessel reactivity, blood pressure, renal hemodynamics, and Na+ excretion rates during various durations of angiotensin II (AngII) infusion as experimental models for hypertension and endothelial dysfunction. Here, AGT is linked to hypertensive disorder.