DNM1L and melanoma: On the other hand, the use of Mdivi-1 led to a decrease in DRP1-dependent mitochondrial fission and dose-dependent apoptosis, which was not seen in the wild type (WT) BRAFWT melanoma cell line, suggesting that the induction of phosphorylated DRP1S616 in dysplastic nevi and in primary melanoma may be a contributing factor to BRAFV600E disease, raising the question of its potential role as a prognosis biomarker in this context [95].