Recently, Guerra et al. have documented an increase in the expression of DRP1 and BNIP3, a molecular mediator which promotes mitophagy, the antioxidant augmenter of liver regeneration (ALR), and the anti-apoptotic molecule BCL-2 in cancer cells of type I endometrial carcinoma with previously described alterations in respiratory complex I (oncocytic-like phenotype), as compared to matched non-malignant tissue and hyperplastic tissue, linking mitochondrial dysfunction to the expression of pro-fission, anti-oxidant, and anti-apoptotic proteins [24]. This evidence concerns the gene DNM1L and cancer.