Moreover, anti-human TIM-3 mouse IgG2a antibodies with complement-dependent and antibody-dependent cellular cytotoxic activities inhibited the engraftment of AML after xenotransplantation and, when administered directly to mice grafted with human AML, they eliminated LSCs capable of reconstituting human AML in secondary recipients [8]. This evidence concerns the gene HAVCR2 and acute myeloid leukemia.