IFNG and acute myeloid leukemia: Interestingly, higher expression levels of IFN-γ pathway genes, including IRF1, MX1, SOCS1, PD-L1 and IFNGR1, may correlate with worse clinical outcome in patients with AML [94,95], as backed by the analysis of patient survival using publicly available transcriptomic data from The Cancer Genome Atlas (TCGA) consortium (http://www.oncolnc.org/, access date: 20 December 2017).