Cycling LSC populations have also been identified in AML harboring KMT2A (MLL) gene rearrangement and are characterized by the expression of CD93 [44], a transmembrane C-type lectin with unknown function that can be detected early during B-cell maturation in the BM and is re-induced during the differentiation on plasmablasts and plasma cells [45]. Here, KMT2A is linked to acute myeloid leukemia.