Suboptimal CNS penetration of ART and multidrug-resistant CNS HIV leads to compartmentalized infection, which manifests in its severest form as HIV encephalopathy.[30,31] However, in our study, we did not find an association between nadir CD4 count and neurosymptomatic CSF/plasma HIV-1 discordance (P = .47). The gene discussed is CD4; the disease is infection.