Platelets are recruited and adhere to tumor cells through platelet receptors, such as glycoprotein IIb/IIIa and P-selectin.[41,42] Additionally, platelets secrete tumor growth factors, such as vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), transforming growth factor-β1 (TGFβ1), and insulin-like growth factor-1 (IGF1).[43] These factors play a crucial role in tumorigenesis, angiogenesis, and metastasis. This evidence concerns the gene IGF1 and neoplasm.