AKT1 and brain neoplasm: Immunostaining of these areas with a panel of antisera (PCNA, AKT1, GFAP and Synaptophysin) showed disrupted cell architecture, with increased mitotic figures, as well as positive staining for AKT1, GFAP and Synaptophysin, suggesting abnormal growth and differentiation, suggestive of brain tumors with mixed neuronal and glial components (Figure 1—figure supplement 1I–N).