Targeted vascular endothelial growth factor (VEGF) inhibitors or epidermal growth factor receptor (EGFR) monoclonal antibodies such as bevacizumab, aflibercept, cetuximab, and panitumumab have been demonstrated to increase pCR rates and improve prognoses for metastatic colorectal cancer (mCRC) patients 13, 14, 15, 16. This evidence concerns the gene EGFR and metastatic colorectal cancer.