In a phase II trial evaluating the FOLFOXIRI + cetuximab regimen on 13 wild-type KRAS exon 2 codon 12 mCRC patients, the RR, median PFS, and median OS were 70% and 10.2 and 30.3 months, respectively, although there were high rates of Grade ≥ 3 neutropenia (23%), diarrhea (53%), and stomatitis (10%) [7]. This evidence concerns the gene KRAS and Decreased total neutrophil count.