Indeed, previous work demonstrates that central Nts promotes DA release, locomotor activity, hypothermia, anorexia, and reward via NtsR1 (Pettibone et al., 2002; Remaury et al., 2002; Leonetti et al., 2004; Kim et al., 2008; Kempadoo et al., 2013; Opland et al., 2013; Rouibi et al., 2015), whereas NtsR2 may confer the pain-reducing effects of Nts (Remaury et al., 2002; Maeno et al., 2004; Roussy et al., 2010; Kleczkowska and Lipkowski, 2013). This evidence concerns the gene NTS and Anorexia.