In addition to several well-known pathways that are related to NAFLD pathology (including fatty acid elongation, AMPK signaling pathway, and NF-kappa B signaling pathway), peroxisome proliferator-activated receptor (PPAR) and hedgehog (Hh) signaling pathways (Table S2) are of special interest because of their essential roles in hepatic fibrosis of NAFLD progression. This evidence concerns the gene PPARA and metabolic dysfunction-associated steatotic liver disease.