EPCAM and skin basal cell carcinoma: BerEP4 was found to be able to differentiate BCC from BD with a specificity and sensitivity of 100% in a study by Ansai et al. (2012), although a recent study by Kogut et al. (2016) reported that BerEP4 expression is not always helpful in distinguishing BD from BCC with around 26% of BD's reacting positively with BerEP4 (at least 5% staining) [39] (Figure 3).