Two metatypical BCC cases with a high rate of postoperative recurrence and metastasis risk [44, 45] as well as two cases of granular BCC found by Claassen et al. (2014) and Jedrych & Busam (2014) were also successfully diagnosed with the help of BerEP4 immunohistochemistry test [46, 47]. The gene discussed is EPCAM; the disease is skin basal cell carcinoma.