Neither age (≤ or >14 years) (p = 0.52), gender (p = 0.74), tumor site (extremity versus axis) (p = 0.76), tumor volume (≤ 200 ml or > 200 ml) (p = 0.52), nor the presence or absence of distant metastases in lungs, bone and/or bone marrow (p = 0.35) was significantly associated with HLA-G expression in the microenvironment of treatment-naive tumor samples. Here, HLA-G is linked to neoplasm.