Notably, in our mouse model, the tumor cells fueled by C-RAF (C-RAF BxB-DsRed) hold a cuboidal morphology whereas the tumors driven by c-MYC (MYC-DsRed) shows columnar cell morphology, which is comparatively larger in size as well as thought to be having a more aggressive phenotype than the cuboidal ones. This evidence concerns the gene RAF1 and neoplasm.